18:27:50 - 24.01.2021
18:27:51 - 24.01.2021
Местоположение

ФОСФОРАЛ РОМФАРМ 3Г. №1 ГРАН. Д/ПРИГ. Р-РА

ФОСФОРАЛ РОМФАРМ 3Г. №1 ГРАН. Д/ПРИГ. Р-РА
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Описание


Фосфорал Ромфарм

К.О. Ромфарм Компани С.Р.Л. (Румыния)

порошок для приготовления раствора для приема внутрь 3 г

Латинское название

Fosforal Rompharm

Действующее вещество

АТХ

Фармакологическая группа

Состав

Один пакетик содержит:

Активное вещество:

Фосфомицина трометамол 5,631 г в пересчете на фосфомицин — 3,000 г;

Вспомогательные вещества:

Кальция гидроксид — 0,300 г, лимонный ароматизатор — 0,200 г, сахарин натрия — 0,010 г, сахарная пудра — до 8,000 г.

Описание лекарственной формы

Гранулы от белого до светло-желтого цвета с лимонным запахом.

Фармакодинамика

Фосфомицин — антибиотик широкого спектра действия фосфоновой кислоты. Бактерицидное действие фосфомицина основано на том, что фосфомицин является структурным аналогом фосфоенол пирувата. Инактивирует N‑ацетил‑глюкозамино‑3‑о‑енолпирувил-трансферазу, необратимо блокирует конденсацию уридиндифосфат-N-ацетил-глюкозамина с фосфоенола пируватом, подавляет синтез УДФ-ГчГ-ацетилмурамовой кислоты, ингибируя таким образом начальный этап образования пептидогликана клеточной стенки бактерий. In vitro фосфомицин снижает адгезию ряда бактерий на эпителии мочевыводящих путей.

In vitro к фосфомицину чувствительны грамположительные (Staphylococcus saprophyticus, Enterococcus faecalis) и грамотрицательные (Escherichia coli, Klebsiella pneumoniae, Citrobacter spp., Enterobacter spp., Proteus mirabilis) микроорганизмы.

Инактивация фермента N-ацетил-глюкозамино-3-о-енолпирувил-трансферазы снижает вероятность возникновения перекрестной резистентности к антибиотикам с аналогичным механизмом действия и создает условия для синергизма (в экспериментах in vitro выявлен синергетический эффект с амоксициллином, цефалексином, пипемидиновой кислотой).

Фармакокинетика

Всасывание

При пероральном приеме, фософомицина трометамол быстро всасывается из желудочно-кишечного тракта. В организме диссоциирует на фосфомицин и трометамол (трометамол не обладает антибактериальными свойствами). Биодоступность при однократном пероральном приеме составляет 32–54%, по сравнению с внутривенным введением. Максимальная плазматическая концентрация фосфомицина достигается через 2–3 часа, с момента приема и составляет 30 мг/л.

Распределение

После приема внутрь фосфомицина трометамол распределяется умеренным образом. Не связывается с белками плазмы, не метаболизируется. Период полувыведения препарата из плазмы составляет от 3 до 4 часов. Максимальные концентрации, более 2000 мг/л в моче достигаются после 2–4 часов, с момента приема.

Концентрация выше минимальной ингибирующей концентрации патогенного агента, который вызывает инфекцию мочевых путей, составляет 128 мг/л и поддерживается не менее 36 часов.

Выведение

Фосфомицин на 90% выводится почками в неизмененном виде, путем клубочковой фильтрации, около 10% в неизмененном виде выводится через кишечник. В случае нарушения функции почек (КК <80 мл/мин), включая физиологическое снижение у лиц пожилого возраста, выведение активного вещества почками задерживается, зависимым образом, от уровня почечной дисфункции, но концентрация в моче остается на терапевтическом уровне.

Показания

Бактериальные инфекции мочевыводящих путей различной локализации, вызываемые чувствительными к фосфомицину микроорганизмами: острые неосложненные инфекции мочевыводящих путей; бессимптомная бактериурия; профилактика инфекций мочевыводящих путей после хирургического вмешательства и трансуретральных диагностических исследований.

Противопоказания

-        повышенная чувствительность к фосфомицину или к другим компонентам препарата;

-        пациенты, находящиеся на диализе;

-        тяжелая степень почечной недостаточности (КК<10 мл/мин);

-        детский возраст до 12 лет;

-        дефицит сахаразы/изомальтазы;

-        непереносимость фруктозы, глюкозо-галактозная мальабсорбция.

Применение при беременности и кормлении грудью

При беременности применяют только в случае, если предполагаемая польза для матери превышает потенциальный риск для плода. При назначении препарата в период лактации необходимо прекратить грудное вскармливание на время терапии.

Способ применения и дозы

ФОСФОРAЛ РОМФАРМ применяют однократно, натощак, за 2–3 ч до или после приема пищи, предпочтительно перед сном, предварительно опорожнив мочевой пузырь: взрослым и детям старше 12 лет в суточной дозе 3 г. Содержимое пакета растворяют в ½ стакана воды. Для профилактики инфекций мочевыводящих путей при хирургическом вмешательстве, диагностических процедурах указанная выше доза принимается 2 раза — за 3 ч до вмешательства и через 24 ч после него.

Побочные действия

Возможны расстройства со стороны желудочно-кишечного тракта (тошнота, изжога, диарея), кожная сыпь, аллергические реакции, головная боль, головокружение, астения, парестезия (ощущение онемения кожи, «ползание мурашек»), неврит зрительного нерва, тахикардия, снижение артериального давления, кожный зуд, бронхиальная астма, ангионевротический отек, крапивница, анафилактический шок, рвота, диспепсия, псевдомембранозный колит, боль в животе, повышение активности «печеночных» трансаминаз, вульвовагинит, тромбоцитоз, лейкопения.

Взаимодействие

Следует избегать одновременного приема с метоклопрамидом, антацидами или препаратами, содержащими соли кальция, так как это может привести к снижению концентрации фосфомицина в сыворотке крови и моче. Одновременный прием с другими препаратами, которые усиливают моторику желудочно-кишечного тракта, также может привести к снижению концентрации фосфомицина в сыворотке крови и моче.

Передозировка

Симптомы передозировки: диарея (при стойкой диарее назначается симптоматическое лечение), вестибулярный синдром, нарушение слуха, «металлический» вкус и общие нарушения вкуса. В случае передозировки рекомендуется повышать диурез приемом жидкости внутрь. Специфический антидот отсутствует.

Особые указания

Применение антибиотиков широкого спектра действия, в том числе фосфомицина трометамола, может привести к возникновению антибиотик-ассоциированного колита (включая псевдомембранозный колит). Поэтому необходимо учитывать вероятность этого диагноза у пациентов, при возникновении сильной диареи во время или после приема фосфомицина трометамола. В случае подтверждения диагноза, необходимо немедленно начать соответствующее лечение, в данном случае препараты, ингибирующие перистальтику, противопоказаны.

Одновременный прием пищи замедляет всасывание фосфомицина. Поэтому желательно применять препарат натощак или через 2–3 часа после еды.

ФОСФОРAЛ РОМФАРМ содержит сахарозу. Больным сахарным диабетом и тем, кому нужно соблюдать диету, следует учитывать, что в 1 пакете ФОСФОРAЛ РОМФАРМ содержится до 1,86 г сахара. ФОСФОРAЛ РОМФАРМ не должен применяться у пациентов с непереносимостью фруктозы, синдромом глюкозо-галактозной мальабсорбции или дефицитом сахаразы-изомальтазы.

Влияние на способность управлять транспортными средствами и механизмами

Пациенты должны быть предупреждены о возможности развития головокружения и при появлении головокружения следует воздержаться от выполнения указанных видов деятельности.

Форма выпуска

Гранулы для приготовления раствора для приема внутрь 3 г.

По 8,0 г препарата в многослойные ламинированные пакетики.

По 1 или 2 пакетика вместе с инструкцией по применению помещают в картонную пачку.

Производитель

Предприятие-производитель/организация, принимающая претензии

К.О. Ромфарм Компани C.P.Л.

075100, ул. Ероилор № 1А, Отопень, уезд Ильфов, Румыния

Претензии по качеству препарата направлять по адресу

Представитель производителя в РФ:

ООО «Ромфарма», Россия

121596, г. Москва, ул. Горбунова д. 2, стр. 204.

Тел./факс: (495) 269-00-39.

Условия отпуска из аптек

По рецепту.

Срок годности препарата Фосфорал Ромфарм

3 года

Хранить в недоступном для детей месте.

Условия хранения препарата Фосфорал Ромфарм

При температуре не выше 25 °C

Не применять по истечении срока годности, указанного на упаковке.

Наличие в аптеках


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    цена: 438 руб.
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[PRINT_DISCOUNT_DIFF] => 0 руб. ) [CATALOG_GROUP_ID_1] => 1 [~CATALOG_GROUP_ID_1] => 1 [CATALOG_GROUP_NAME_1] => Розничная цена [~CATALOG_GROUP_NAME_1] => Розничная цена [CATALOG_CAN_ACCESS_1] => Y [~CATALOG_CAN_ACCESS_1] => Y [CATALOG_CAN_BUY_1] => Y [~CATALOG_CAN_BUY_1] => Y [CATALOG_PRICE_ID_1] => 633625044 [~CATALOG_PRICE_ID_1] => 633625044 [CATALOG_PRICE_1] => 93.00 [~CATALOG_PRICE_1] => 93.00 [CATALOG_CURRENCY_1] => RUB [~CATALOG_CURRENCY_1] => RUB [CATALOG_QUANTITY_FROM_1] => [~CATALOG_QUANTITY_FROM_1] => [CATALOG_QUANTITY_TO_1] => [~CATALOG_QUANTITY_TO_1] => [CATALOG_EXTRA_ID_1] => [~CATALOG_EXTRA_ID_1] => [ID] => 405522 [~ID] => 405522 [IBLOCK_ID] => 26 [~IBLOCK_ID] => 26 [CODE] => azitromitsin-500mg-3-kaps-proizvodstvo-medikamentov-promed [~CODE] => azitromitsin-500mg-3-kaps-proizvodstvo-medikamentov-promed [XML_ID] => 00-00008197 [~XML_ID] => 00-00008197 [NAME] => АЗИТРОМИЦИН 500МГ. №3 КАПС. /ПРОИЗВОДСТВО МЕДИКАМЕНТОВ/ ПроМед/ [~NAME] => АЗИТРОМИЦИН 500МГ. №3 КАПС. /ПРОИЗВОДСТВО МЕДИКАМЕНТОВ/ ПроМед/ [ACTIVE] => Y [~ACTIVE] => Y [DATE_ACTIVE_FROM] => [~DATE_ACTIVE_FROM] => [DATE_ACTIVE_TO] => [~DATE_ACTIVE_TO] => [SORT] => 500 [~SORT] => 500 [PREVIEW_TEXT] => [~PREVIEW_TEXT] => [PREVIEW_TEXT_TYPE] => text [~PREVIEW_TEXT_TYPE] => text [DETAIL_TEXT] => [~DETAIL_TEXT] => [DETAIL_TEXT_TYPE] => text [~DETAIL_TEXT_TYPE] => text [DATE_CREATE] => 17.05.2020 12:51:11 [~DATE_CREATE] => 17.05.2020 12:51:11 [CREATED_BY] => 0 [~CREATED_BY] => 0 [TAGS] => [~TAGS] => [TIMESTAMP_X] => 24.01.2021 16:15:34 [~TIMESTAMP_X] => 24.01.2021 16:15:34 [MODIFIED_BY] => 0 [~MODIFIED_BY] => 0 [IBLOCK_SECTION_ID] => 17548 [~IBLOCK_SECTION_ID] => 17548 [DETAIL_PAGE_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/azitromitsin-500mg-3-kaps-proizvodstvo-medikamentov-promed/ [~DETAIL_PAGE_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/azitromitsin-500mg-3-kaps-proizvodstvo-medikamentov-promed/ [DETAIL_PICTURE] => [~DETAIL_PICTURE] => [PREVIEW_PICTURE] => Array ( [ID] => 0 [SRC] => /local/templates/gorapteka_ru/components/bitrix/catalog.section/main/images/no_photo.png [WIDTH] => 500 [HEIGHT] => 500 ) [~PREVIEW_PICTURE] => [LANG_DIR] => / [~LANG_DIR] => / [SHOW_COUNTER] => 864 [~SHOW_COUNTER] => 864 [SHOW_COUNTER_START_X] => 2020-06-16 08:04:06 [~SHOW_COUNTER_START_X] => 2020-06-16 08:04:06 [EXTERNAL_ID] => 00-00008197 [~EXTERNAL_ID] => 00-00008197 [IBLOCK_TYPE_ID] => catalog [~IBLOCK_TYPE_ID] => catalog [IBLOCK_CODE] => catalog [~IBLOCK_CODE] => catalog [IBLOCK_EXTERNAL_ID] => main_catalog [~IBLOCK_EXTERNAL_ID] => main_catalog [LID] => s1 [~LID] => s1 [ACTIVE_FROM] => [ACTIVE_TO] => [IPROPERTY_VALUES] => Array ( [ELEMENT_META_KEYWORDS] => АЗИТРОМИЦИН 500МГ. №3 КАПС. /ПРОИЗВОДСТВО МЕДИКАМЕНТОВ/ ПроМед/ от 93 руб. в аптеках г. 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[MIN_QUANTITY] => 1 ) ) [ITEM_QUANTITY_RANGES] => Array ( [ZERO-INF] => Array ( [HASH] => ZERO-INF [QUANTITY_FROM] => [QUANTITY_TO] => [SORT_FROM] => 0 [SORT_TO] => INF ) ) [ITEM_MEASURE_RATIOS] => Array ( [0] => Array ( [ID] => 0 [RATIO] => 1 [IS_DEFAULT] => Y ) ) [ITEM_MEASURE] => Array ( [ID] => [TITLE] => шт [~TITLE] => шт ) [ITEM_MEASURE_RATIO_SELECTED] => 0 [ITEM_QUANTITY_RANGE_SELECTED] => ZERO-INF [ITEM_PRICE_SELECTED] => 0 [CATALOG_MEASURE_NAME] => шт [~CATALOG_MEASURE_NAME] => шт [EDIT_LINK] => [DELETE_LINK] => [SECTION] => Array ( [PATH] => Array ( ) ) [CAN_BUY] => 1 [ITEM_PRICES_CAN_BUY] => 1 [~BUY_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=BUY&id=405522 [BUY_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=BUY&id=405522 [~ADD_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=ADD2BASKET&id=405522 [ADD_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=ADD2BASKET&id=405522 [~SUBSCRIBE_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=SUBSCRIBE_PRODUCT&id=405522 [SUBSCRIBE_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=SUBSCRIBE_PRODUCT&id=405522 [CATALOG_MEASURE_RATIO] => 1 [CATALOG] => 1 [CATALOG_SUBSCRIPTION] => N [BIG_DATA] => [LABEL] => [LABEL_VALUE] => [LABEL_ARRAY_VALUE] => Array ( ) [LABEL_PROP_MOBILE] => Array ( ) [PROPERTY_CODE_MOBILE] => Array ( ) [ENLARGED] => N [SHOW_SLIDER] => 1 [MORE_PHOTO] => Array ( [0] => Array ( [ID] => 0 [SRC] => /local/templates/gorapteka_ru/components/bitrix/catalog.section/main/images/no_photo.png [WIDTH] => 500 [HEIGHT] => 500 ) ) [MORE_PHOTO_COUNT] => 1 [PREVIEW_PICTURE_SECOND] => Array ( [ID] => 0 [SRC] => /local/templates/gorapteka_ru/components/bitrix/catalog.section/main/images/no_photo.png [WIDTH] => 500 [HEIGHT] => 500 ) [SECOND_PICT] => 1 [PRODUCT_PREVIEW] => Array ( [ID] => 0 [SRC] => /local/templates/gorapteka_ru/components/bitrix/catalog.section/main/images/no_photo.png [WIDTH] => 500 [HEIGHT] => 500 ) [PRODUCT_PREVIEW_SECOND] => Array ( [ID] => 0 [SRC] => /local/templates/gorapteka_ru/components/bitrix/catalog.section/main/images/no_photo.png [WIDTH] => 500 [HEIGHT] => 500 ) [RATIO_PRICE] => Array ( [VALUE] => 93 [DISCOUNT_VALUE] => 93 [PRINT_VALUE] => 93 руб. 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[MIN_QUANTITY] => 1 ) ) [ITEM_QUANTITY_RANGES] => Array ( [ZERO-INF] => Array ( [HASH] => ZERO-INF [QUANTITY_FROM] => [QUANTITY_TO] => [SORT_FROM] => 0 [SORT_TO] => INF ) ) [ITEM_MEASURE_RATIOS] => Array ( [0] => Array ( [ID] => 0 [RATIO] => 1 [IS_DEFAULT] => Y ) ) [ITEM_MEASURE] => Array ( [ID] => [TITLE] => шт [~TITLE] => шт ) [ITEM_MEASURE_RATIO_SELECTED] => 0 [ITEM_QUANTITY_RANGE_SELECTED] => ZERO-INF [ITEM_PRICE_SELECTED] => 0 [CATALOG_MEASURE_NAME] => шт [~CATALOG_MEASURE_NAME] => шт [EDIT_LINK] => [DELETE_LINK] => [SECTION] => Array ( [PATH] => Array ( ) ) [CAN_BUY] => 1 [ITEM_PRICES_CAN_BUY] => 1 [~BUY_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=BUY&id=407890 [BUY_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=BUY&id=407890 [~ADD_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=ADD2BASKET&id=407890 [ADD_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=ADD2BASKET&id=407890 [~SUBSCRIBE_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=SUBSCRIBE_PRODUCT&id=407890 [SUBSCRIBE_URL] => /catalog/lekarstva-i-bady/antibiotiki-vnutr-dlya-vzroslykh/fosforal-romfarm-3g-1-gran-d-prig-r-ra/?action=SUBSCRIBE_PRODUCT&id=407890 [CATALOG_MEASURE_RATIO] => 1 [CATALOG] => 1 [CATALOG_SUBSCRIPTION] => N [BIG_DATA] => [LABEL] => [LABEL_VALUE] => [LABEL_ARRAY_VALUE] => Array ( ) [LABEL_PROP_MOBILE] => Array ( ) [PROPERTY_CODE_MOBILE] => Array ( ) [ENLARGED] => N [SHOW_SLIDER] => 1 [MORE_PHOTO] => Array ( [0] => Array ( [ID] => 0 [SRC] => /local/templates/gorapteka_ru/components/bitrix/catalog.section/main/images/no_photo.png [WIDTH] => 500 [HEIGHT] => 500 ) ) [MORE_PHOTO_COUNT] => 1 [PREVIEW_PICTURE_SECOND] => Array ( [ID] => 2883003 [SRC] => /upload/iblock/81f/00_00011049.jpg [WIDTH] => 640 [HEIGHT] => 480 ) [SECOND_PICT] => 1 [PRODUCT_PREVIEW] => Array ( [ID] => 2883003 [SRC] => /upload/iblock/81f/00_00011049.jpg [WIDTH] => 640 [HEIGHT] => 480 ) [PRODUCT_PREVIEW_SECOND] => Array ( [ID] => 2883003 [SRC] => /upload/iblock/81f/00_00011049.jpg [WIDTH] => 640 [HEIGHT] => 480 ) [RATIO_PRICE] => Array ( [VALUE] => 329 [DISCOUNT_VALUE] => 329 [PRINT_VALUE] => 329 руб. 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[PRINT_DISCOUNT_VALUE_NOVAT] => 718 руб. [PRINT_DISCOUNT_VALUE_VAT] => 718 руб. [PRINT_DISCOUNT_VATRATE_VALUE] => 0 руб. [PRINT_VALUE] => 718 руб. [PRINT_DISCOUNT_VALUE] => 718 руб. [PRINT_DISCOUNT_DIFF] => 0 руб. ) ) [PRICE_MATRIX] => [MIN_PRICE] => Array ( [PRICE_ID] => 1 [ID] => 633585809 [CAN_ACCESS] => Y [CAN_BUY] => Y [MIN_PRICE] => Y [CURRENCY] => RUB [VALUE_VAT] => 718 [VALUE_NOVAT] => 718 [DISCOUNT_VALUE_VAT] => 718 [DISCOUNT_VALUE_NOVAT] => 718 [ROUND_VALUE_VAT] => 718 [ROUND_VALUE_NOVAT] => 718 [VALUE] => 718 [UNROUND_DISCOUNT_VALUE] => 718 [DISCOUNT_VALUE] => 718 [DISCOUNT_DIFF] => 0 [DISCOUNT_DIFF_PERCENT] => 0 [VATRATE_VALUE] => 0 [DISCOUNT_VATRATE_VALUE] => 0 [ROUND_VATRATE_VALUE] => 0 [PRINT_VALUE_NOVAT] => 718 руб. [PRINT_VALUE_VAT] => 718 руб. [PRINT_VATRATE_VALUE] => 0 руб. [PRINT_DISCOUNT_VALUE_NOVAT] => 718 руб. [PRINT_DISCOUNT_VALUE_VAT] => 718 руб. [PRINT_DISCOUNT_VATRATE_VALUE] => 0 руб. [PRINT_VALUE] => 718 руб. [PRINT_DISCOUNT_VALUE] => 718 руб. 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